Understanding Possible Side Effects

The immune system plays a crucial role in the development and progression of hypothyroidism, particularly in the most common form, Hashimoto's thyroiditis. In Hashimoto's thyroiditis, the immune system mistakenly attacks the thyroid gland, causing inflammation and impairing its ability to produce thyroid hormones. Over time, this leads to a decrease in the production of these hormones, resulting in hypothyroidism. Hypothyroidism, also known as underactive thyroid disease, is a common condition where the thyroid gland doesn't produce enough hormones. These hormones play a crucial role in orchestrating the body's metabolism—the way your body uses energy. When the thyroid is underactive, every function in the body slows down, leading to various symptoms.

Biotin supplementation is known to interfere with thyroid hormone immunoassays that are based on a biotin and streptavidin interaction, which may result in erroneous thyroid hormone test results. Stop biotin and biotin-containing supplements for at least 2 days prior to thyroid testing. Seizures have been reported rarely with the institution of levothyroxine therapy. Start at a lower starting dosage and increase the dosage every 4 to 6 weeks as needed based on clinical and laboratory response. While the link between hypothyroidism and UTIs is not fully established, it's still important to take steps to prevent UTIs, especially if you have an underactive thyroid. These include drinking plenty of fluids, urinating regularly, avoiding holding in urine, wearing breathable cotton underwear, and practicing good hygiene.

Can Hypothyroidism Cause UTI?

Menarini Diagnostic, and serum sodium, potassium, urea, creatinine, chloride and glucose concentrations were measured by Roche/Hitachi cobas c systems. The eGFR was computed automatically with the Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI). Sodium, urea, and creatinine concentrations were also measured in urine samples by Roche/Hitachi cobas c systems. A urinary tract infection (UTI) is an infection that affects any part of theurinary system, including the kidneys, bladder, ureters, and urethra. Commonsymptoms of a UTI include frequent urination, a strong urge to urinate, painor burning sensation during urination, cloudy or bloody urine, and pelvicpain.

Statistical Analysis

• Moreover, thyroid hormones play a role in the maturation and proliferation of immune cells, so a deficiency in these hormones can affect the function and responsiveness of the immune system.
• Hypothyroidism, a condition marked by an underactive thyroid gland, can manifest through a multitude of symptoms, often making it a complex condition to diagnose.
• Hypothyroidism can affect various body functions, including the immune system, potentially making an individual more susceptible to infections.

These include urticaria, pruritus, skin rash, flushing, angioedema, various gastrointestinal symptoms (abdominal pain, nausea, vomiting and diarrhea), fever, arthralgia, serum sickness, and wheezing. The recommended starting daily dosage of SYNTHROID in pediatric patients with primary, secondary, or tertiary hypothyroidism is based on body weight and changes with age as synthroid overdose described in Table 2. Titrate the dosage (every 2 weeks) as needed based on serum TSH or free- T4 until the patient is euthyroid see Important Considerations For Dosing. An enlarged thyroid gland, also known as a goiter, is often a sign of thyroid dysfunction. While it doesn't directly increase the risk of UTIs, the underlying thyroid dysfunction could affect the body's immune response and susceptibility to infections.

Dosing And Administration

Concurrent use of sympathomimetics and SYNTHROID may increase the effects of sympathomimetics or thyroid hormone. Thyroid hormones may increase the risk of coronary insufficiency when sympathomimetic agents are administered to patients with coronary artery disease. TSH may not normalize in some patients due to in utero hypothyroidism causing a resetting of pituitary-thyroid feedback. Assess compliance, dose of medication administered, and method of administration prior to increasing the dose of SYNTHROID see WARNINGS AND PRECAUTIONS and Use In Specific Populations. For secondary or tertiary hypothyroidism, serum TSH is not a reliable measure of SYNTHROID dosage adequacy and should not be used to monitor therapy.

TSH, which is released from the pituitary gland, regulates the production of thyroid hormone, but TSH itself does not act as thyroid hormone. Therefore, FT4 is more representative of thyroid function rather than TSH. Considering the aforementioned issues, our results showing that TSH is not related to LUTS/BPH measurements does not hinder the fact that thyroid function is related to LUTS/BPH.

However, we think that our data are highly relevant because this study was a large cross-sectional study. Mean TPV, IPSS, and Qmax was 24.1±7.0 mL, 10.6±7.1, and 23.0±8.6 mL/s, respectively. In addition, the ratio of MetS was 41.9%, and the median PVR (interquartile range) was 0 mL (0–38.0 mL).

For healthcare professionals

Increased awareness of this link among healthcare providers and patients can promote early detection and treatment, potentially mitigating the risk of serious complications. Moreover, individuals with hypothyroidism should be educated on the importance of regular check-ups and adequate disease management to prevent potential health issues, including UTIs. Hypothyroidism, a condition marked by an underactive thyroid gland, can manifest through a multitude of symptoms, often making it a complex condition to diagnose. A question that frequently arises in the realm of health discussions is whether hypothyroidism can cause urinary tract infections (UTIs).

Thyroid and Interstitial Cystitis (IC) and Recurrent Bladder Infection

Because of the increased prevalence of cardiovascular disease among the elderly, initiate SYNTHROID at less than the full replacement dose see DOSAGE AND ADMINISTRATION and WARNINGS AND PRECAUTIONS. Atrial fibrillation is the most common of the arrhythmias observed with levothyroxine overtreatment in the elderly. Addition of levothyroxine therapy in patients with diabetes mellitus may worsen glycemic control and result in increased antidiabetic agent or insulin requirements. Carefully monitor glycemic control after starting, changing, or discontinuing SYNTHROID see DRUG INTERACTIONS. Over-treatment with levothyroxine may cause an increase in heart rate, cardiac wall thickness, and cardiac contractility and may precipitate angina or arrhythmias, particularly in patients with cardiovascular disease and in elderly patients. Initiate SYNTHROID therapy in this population at lower doses than those recommended in younger individuals or in patients without cardiac disease see DOSAGE AND ADMINISTRATION and Use In Specific Populations.

The static component of bladder outlet obstruction was induced by the anatomic obstruction resulting from enlargement of the prostate. Free thyroxine (FT4) and thyroid-stimulating hormone (TSH) were estimated by chemiluminescence (Advia Centaur CP, Erlangen, Germany) using reagent kits from Siemens Diagnostic (Erlangen, Germany). The intra-assay coefficients of variation for all assays were less than 9%, and the inter-assay coefficients of variation were less than 12%. Total prostate volume (TPV) was calculated using transrectal ultrasonography (UltraView 800; BK Medical).